Highly potent molecules
Holochem supports its customers with the synthesis and development of High Potency APIs (HPAPIs) and Antibody Drug Conjugate (ADC) linkers.
High Potency APIs (HPAPIs)
Antibody Drug Conjugate (ADC) linkers
Highly Potent cytotoxic molecules have high toxicity when unconjugated, as well as chemo-selectivity and stability issues. Strong expertise in hazardous chemistry and recent investments in high-containment facilities enable us to synthesise and develop cytotoxic and highly potent drug compounds.
We have dedicated labs for HPAPIs where we can safely handle high toxicity molecules and potent materials with high Occupational Exposure Levels (OEL) of 1mg/m3.
Our team has already successfully developed several Highly Potent APIs and payload linker conjugates.