Holochem offers a full range of chemical development and pre-clinical chemistry services for the early-phase supply of drug substances.
Thorough understanding of project needs and constraints along with in-depth scientific expertise enable us to provide best-in-class route scouting and multi-step custom synthesis for a wide range of compounds; key intermediates and Active Pharmaceutical Ingredients, including Highly potent APIs and ADC linkers, as well as reference standards, process impurities, degradation products and metabolites.
We value close collaboration and open communication at all stages of the development process and have established long-term partnerships with suppliers to guarantee qualitative starting materials.
Strict quality control is conducted at every step of the development process to ensure save products. Batch records and samples are filed throughout the synthesis process to ensure full traceability. All compounds are delivered with their Certificate of Analysis.
We attach highest importance to in-time delivery of high-quality compounds. Collaboration is based on strict confidentiality and IP protection with complete technology transfer.
We conduct process research to identify the best route to the desired compound in line with customer’s specifications and budget constraints.
Whether compounds are already described in literature or not, we can find the most efficient and cost-effective routes to synthesize existing compounds or generic active ingredients based on bibliographical research, or start from scratch and identify new, innovative chemical routes to design new chemical entities.
Our scientific team is particularly experienced in multi-step custom synthesis of small and complex compounds. Our scientists have strong and solid expertise in sophisticated, exclusive synthesis with high purity levels, and have often contributed to solving complex chemistry issues.
Our robust synthesis processes are optimized for scale-up and process repeatability, and strictly comply with all regulatory, environmental and customer requirements.